Medicinal Chemistry
Medicinal chemistry means different things to different people. One
man's
meat is another man's poison. Irrespective of whether you wish to synthesize
small organic molecules for biological testing in the animal or plant
kingdom, I can offer insight based on experience and a survey of
of the relevant
literature.
My earliest experience (1975) in the synthesis, purification and spectral
characterization of organic molecules for biological screening concerned
a disease called coccidiosis which afflicts chickens. Several
3-acyl-4-hydroxycoumarins and a few thiocoumarins were synthesized, purified
by recrystallization and the structures verified by nmr spectroscopy.
Criteria of purity included satisfactory elemental analyses (varying by not
more than 0.05%). The synthesis and provision of molecules for application
as standards in both discovery and early process environments constitutes
part and parcel of my experience, which includes a
diversity of organic molecules.
Other areas of experience include synthesis of anti-hyperglycemic agents and
molecules which can interfere with platelet aggregation.
There is much confusion today about the molecular events leading to
the
development of long-term complications of diabetes type 2. You can
gain
perspective not easily rendered by the medical profession or the supplement
industry by sending me your inquiry by
e-mail.