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Medicinal Chemistry

Medicinal chemistry means different things to different people. One
man's meat is another man's poison. Irrespective of whether you wish to synthesize small organic  molecules for biological testing in the animal or plant kingdom, I can offer insight based on experience and a survey  of
of the relevant literature.

My earliest experience (1975) in the synthesis, purification and spectral characterization of organic molecules for biological screening concerned
a disease called coccidiosis which afflicts chickens. Several 3-acyl-4-hydroxycoumarins and a few thiocoumarins were synthesized, purified by recrystallization and the structures verified by nmr spectroscopy. Criteria of purity included satisfactory elemental analyses (varying by not
more than 0.05%). The synthesis and provision of molecules for application as standards in both discovery and early process environments constitutes part and parcel of my experience, which includes a diversity of organic molecules.

Other areas of experience include synthesis of anti-hyperglycemic agents and molecules which can interfere with platelet aggregation.

There is much confusion  today about the molecular events leading to the
development of long-term complications of diabetes type 2.  You can gain
perspective not easily rendered by the medical profession or the supplement industry by sending me your inquiry by e-mail.




 












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